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https://biore.bio.bg.ac.rs/handle/123456789/2927| Title: | Diarylheptanoids from green alder bark and their potential for DNA protection | Authors: | Novaković, Miroslav Stanković, Miroslava Vučković, Ivan Todorović, Nina Trifunović, Snežana Apostolović, Danijela Mandić, Boris Veljić, Milan Marin, Petar Tešević, Vele Vajs, Vlatka Milosavljević, Slobodan |
Keywords: | Cytokinesis-block micronucleus (CBMN) assay;Green alder;Heptanoids;diaryl | Issue Date: | 1-Jan-2014 | Journal: | Chemistry and Biodiversity | Abstract: | Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine. Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/2927 | ISSN: | 1612-1872 | DOI: | 10.1002/cbdv.201300277 |
| Appears in Collections: | Journal Article |
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