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Title: | Noradrenaline through β-adrenoceptor contributes to sexual dimorphism in primary CD4+ T-cell response in DA rat EAE model? | Authors: | Vujnović, Ivana Pilipović, Ivan Jasnić, Nebojša Petrović, Raisa Blagojević, Veljko Arsenović-Ranin, Nevena Stojić-Vukanić, Zorica Đorđević, Jelena Leposavić, Gordana |
Keywords: | CD4+ cell proliferation;Draining lymph nodes;EAE;Noradrenaline;Th17 differentiation;β-Adrenoceptor | Issue Date: | 1-Feb-2019 | Rank: | M22 | Journal: | Cellular Immunology | Abstract: | Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female and male EAE rat draining lymph node (dLN) cell cultures was examined. Male rat dLNs exhibited higher noradrenaline concentration and frequency of β 2 -adrenoceptor–expressing CD4+ T lymphocytes and antigen presenting cells. Propranolol, irrespective of exogenous noradrenaline presence, more prominently augmented IL-2 production and proliferation of CD4+ lymphocytes in male than female rat dLN cell cultures. In neuroantigen-stimulated dLN cells of both sexes propranolol increased IL-1β and IL-23/p19 expression and IL-17+ CD4+ cell frequency, but enhanced IL-17 production only in male rat CD4+ lymphocytes, thereby abrogating sexual dimorphism in IL-17 concentration observed in propranolol-free cultures. Thus, β-adrenoceptor–mediated signalling may contribute to sex bias in rat IL-17–producing cell secretory capacity. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/29 | ISSN: | 0008-8749 | DOI: | 10.1016/j.cellimm.2018.12.009 |
Appears in Collections: | Journal Article |
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