Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/29
Title: Noradrenaline through β-adrenoceptor contributes to sexual dimorphism in primary CD4+ T-cell response in DA rat EAE model?
Authors: Vujnović, Ivana
Pilipović, Ivan
Jasnić, Nebojša 
Petrović, Raisa
Blagojević, Veljko
Arsenović-Ranin, Nevena
Stojić-Vukanić, Zorica
Đorđević, Jelena 
Leposavić, Gordana
Keywords: CD4+ cell proliferation;Draining lymph nodes;EAE;Noradrenaline;Th17 differentiation;β-Adrenoceptor
Issue Date: 1-Feb-2019
Rank: M22
Journal: Cellular Immunology
Abstract: 
Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female and male EAE rat draining lymph node (dLN) cell cultures was examined. Male rat dLNs exhibited higher noradrenaline concentration and frequency of β 2 -adrenoceptor–expressing CD4+ T lymphocytes and antigen presenting cells. Propranolol, irrespective of exogenous noradrenaline presence, more prominently augmented IL-2 production and proliferation of CD4+ lymphocytes in male than female rat dLN cell cultures. In neuroantigen-stimulated dLN cells of both sexes propranolol increased IL-1β and IL-23/p19 expression and IL-17+ CD4+ cell frequency, but enhanced IL-17 production only in male rat CD4+ lymphocytes, thereby abrogating sexual dimorphism in IL-17 concentration observed in propranolol-free cultures. Thus, β-adrenoceptor–mediated signalling may contribute to sex bias in rat IL-17–producing cell secretory capacity.
URI: https://biore.bio.bg.ac.rs/handle/123456789/29
ISSN: 0008-8749
DOI: 10.1016/j.cellimm.2018.12.009
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