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Title: | Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management | Authors: | Jankovic, Aleksandra Korać, Aleksandra Buzadzic, Biljana Stancic, Ana Otasevic, Vesna Ferdinandy, Péter Daiber, Andreas Korać, Bato |
Issue Date: | 1-Jan-2017 | Rank: | M21a | Project: | European Cooperation in Science and Research. Grant Number: BM1203/EU‐ROS White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders |
Journal: | British Journal of Pharmacology | Abstract: | © 2016 The British Pharmacological Society Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel-buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (О 2•– ) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/О 2•– ratio ‘teetering’ as a promising pharmacological target in the metabolic syndrome. Linked Articles: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/274 | ISSN: | 0007-1188 | DOI: | 10.1111/bph.13498 |
Appears in Collections: | Journal Article |
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