Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2491
Title: Anticancer and antimicrobial properties of imidazolium based ionic liquids with salicylate anion
Authors: Јovanović-Šanta, Suzana
Kojić, Vesna
Atlagić, Kristina 
Tot, Aleksandar
Vraneš, Milan
Gadžurić, Slobodan
Karaman, Maja
Keywords: ionic liquids;imidazolium;salicylate;cytotoxicity;antibacterial activity;antifungal activity
Issue Date: Sep-2019
Rank: M23
Journal: Journal of the Serbian Chemical Society
Abstract: 
Ionic liquids (ILs) are well known for their physico-chemical properties which recommend them for many purposes. Still, many of ILs are not environmentally friendly. Having in minds these facts, we designed a series of imidazolium-and salicylate-based ILs with low general toxicity and studied their pharmacological potential. Here we present their antiproliferative effect against human cancer cell lines and antimicrobial activity on selected Gram-positive and Gram-negative bacterial and Candida strains. ILs with 1-butyl-3-methyl­imi­dazolium or imidazolium cation (ILs 1 and 5), with the lowest dipole moments and highest lipophilicity, exerted highest cytotoxicity against colon and/or lung cancer cells, manifesting high selectivity to the normal cells. The most non-polar IL with 1-butyl-3-methylimidazolium cation expressed the strongest anticancer poten­tial, but it was toxic against normal cells as well, although its cytotoxicity was less than the cytotoxic effect of commercially used chemotherapeutic agents. The same compounds (ILs 1 and 5) expressed modest effect on the bacterial strains which causes serious lung diseases and pulmonary infections (S. aureus) or which are included in colon cancer formation (E. coli and E. faecalis). Salicylate itself was toxic against lung cancer cell line A549 and affected some Candida strains.
URI: https://biore.bio.bg.ac.rs/handle/123456789/2491
DOI: 10.2298/JSC190717098J
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