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Title: | Acute effect of cold on the antioxidant enzymes activities and uncoupling protein-1 content in the brown fat of 6-hydroxydopamine-treated rats | Authors: | Davidović, Vukosava Petrović, Nataša Đorđević, Jelena Đurašević, Siniša Cvijić, Gordana |
Keywords: | 6-hydroxydopamine;Antioxidant enzymes;Cold;Interscapular brown adipose tissue;Monoamine oxidase;Rats;Uncoupling protein-1 | Issue Date: | 1-Oct-2004 | Journal: | Journal of Thermal Biology | Abstract: | Uncoupling protein-1 (UCP-1) content and activity of antioxidant enzymes, copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD) and catalase (CAT), as well as that of the monoamine oxidase (MAO) in the interscapular brown adipose tissue (IBAT) of 6-hydroxydopamine (6-HDA)-treated rats at 22°C or cold (4°C, 4 h), were studied.Results indicate that the intact sympathetic nerves (SN) are necessary for the maintenance of basal level of IBAT UCP-1 t and SODs, but not for MAO. They also suggest that in the regulation of IBAT UCP-1 content, in 6-HAD-treated rats exposed to cold, in which this was normalized, and other mechanisms rather than SN are involved. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/241 | ISSN: | 0306-4565 | DOI: | 10.1016/j.jtherbio.2004.08.067 |
Appears in Collections: | Journal Article |
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