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Title: | The activities of antioxidant enzymes and monoamine oxidase and uncoupling protein 1 content in brown fat of hypo- and hyperthyroid rats | Authors: | Petrović, Nataša Cvijić, Gordana Đorđević, Jelena Davidović, Vukosava |
Keywords: | Antioxidant enzymes;Brown fat;Monoamine oxidase;Thyroid hormones;UCP1 | Issue Date: | 1-Jan-2005 | Journal: | Annals of the New York Academy of Sciences | Abstract: | We have studied the activities of antioxidant enzymes (AOE), namely, copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), and catalase (CAT), and the activity of catecholamine-degrading enzyme monoamine oxidase (MAO) and uncoupling protein 1 (UCP1) content in brown fat (BF) of hypo- and hyperthyroid rats. We found that hypothyroidism decreased BF UCP1 content and increased MAO, MnSOD, and CAT activities. T3 increased UCP1 content and MnSOD activity and decreased CuZnSOD, MAO, and CAT activities, while T4 significantly altered (decreased) only CAT activity. This study shows that UCP1 content and MAO and AOE activities in rat BF are notably affected by changed thyroid status. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/239 | ISSN: | 0077-8923 | DOI: | 10.1196/annals.1327.082 |
Appears in Collections: | Journal Article |
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