Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2012
Title: Oxidative stress parameters in two Pelophylax esculentus complex frogs during pre- and post-hibernation: Arousal vs heavy metals
Authors: Prokić, Marko
Borković-Mitić, Slavica
Krizmanić, Imre 
Mutić, Jelena
Gavrić, Jelena
Despotović, Svetlana
Gavrilović, Branka
Radovanović, Tijana
Pavlović, Slađan
Saičić, Zorica.
Keywords: Antioxidative defense system;Arousal;Frogs;Heavy metals;Oxidative stress;Pelophylax esculentus;Pelophylax ridibundus
Issue Date: 1-Nov-2017
Rank: M21a
Project: Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress 
Journal: Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Volume: 202
Start page: 19
End page: 25
Abstract: 
© 2017 Elsevier Inc. In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P. ridibundus and P. esculentus) inhabiting two localities (the Danube-Tisza-Danube canal and the Ponjavica River) with different levels of pollution during pre- and post-hibernation periods, respectively autumn and spring. Our results showed that even though there were differences in the concentrations of accumulated metals and AOS parameters between localities and species, the frogs displayed almost the same patterns of AOS variations during seasons, with a higher AOS response observed in spring. The parameters SH groups, GSH, GR and SOD had been contributed most rather than others. Our findings indicate that oxidative stress during the post-hibernation period was mainly caused by the organisms’ recovery from hibernation, as the result of natural selection acting on the AOS, and that the accumulated metals did not significantly modify the AOS response. The present study provides new insight into the biological and physiological cellular responses of frogs to arousal stress.
URI: https://biore.bio.bg.ac.rs/handle/123456789/2012
ISSN: 1532-0456
DOI: 10.1016/j.cbpc.2017.07.006
Appears in Collections:Journal Article

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