Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/185
Title: Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: Involvement of MMP-2
Authors: Smiljanić, Katarina
Obradović, Milan
Jovanović, Aleksandra
Đorđević, Jelena 
Dobutović, Branislava
Jevremović, Danimir
Marche, Pierre
Isenović, Esma
Keywords: Atherosclerosis;EGFR transactivation;Heparin-binding epidermal growth factor like;Matrix metalloproteinase;MMP-2;Pathological VSMC proliferation;Thrombin signaling cascade
Issue Date: 1-Jan-2014
Journal: Molecular and Cellular Biochemistry
Abstract: 
In this study, the role of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2), heparin-binding EGF-like growth factor (HB-EGF), general metalloproteinases, matrix metalloproteinases-2 (MMP-2) in mediating the mitogenic action of thrombin in rat vascular smooth muscle cells (VSMC) was investigated. The incubation of rat VSMC with thrombin (1 U/ml) for 5 min resu...
URI: https://biore.bio.bg.ac.rs/handle/123456789/185
ISSN: 0300-8177
DOI: 10.1007/s11010-014-2151-y
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