Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/185
Title: | Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: Involvement of MMP-2 |
Authors: | Smiljanić, Katarina Obradović, Milan Jovanović, Aleksandra Đorđević, Jelena Dobutović, Branislava Jevremović, Danimir Marche, Pierre Isenović, Esma |
Keywords: | Atherosclerosis;EGFR transactivation;Heparin-binding epidermal growth factor like;Matrix metalloproteinase;MMP-2;Pathological VSMC proliferation;Thrombin signaling cascade |
Issue Date: | 1-Jan-2014 |
Journal: | Molecular and Cellular Biochemistry |
Abstract: | In this study, the role of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2), heparin-binding EGF-like growth factor (HB-EGF), general metalloproteinases, matrix metalloproteinases-2 (MMP-2) in mediating the mitogenic action of thrombin in rat vascular smooth muscle cells (VSMC) was investigated. The incubation of rat VSMC with thrombin (1 U/ml) for 5 min resu... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/185 |
ISSN: | 0300-8177 |
DOI: | 10.1007/s11010-014-2151-y |
Appears in Collections: | Journal Article |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.