Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/155
Title: Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida)
Authors: Ilić, Bojan 
Unković, Nikola 
Ćirić, Ana
Glamočlija, Jasmina
Ljaljević Grbić, Milica 
Raspotnig, Günther
Bodner, Michaela
Vukojević, Jelena 
Makarov, Slobodan 
Keywords: Antibacterial and antifungal activity;Gas chromatography mass spectrometry;Microdilution;Millipedes;Pathogens
Issue Date: 17-Jun-2019
Rank: M22
Publisher: Springer
Project: Ontogenetic characterization of phylogenetic biodiversity 
Characterization and application of fungal metabolites and assessment of new biofungicides potential 
WTZ project no. SRB 19/ 2018
Journal: The Science of Nature
Abstract: 
Millipedes use an array of chemical compounds to defend themselves from predator attack. These chemical substances can have additional roles, i.e. defence against various pathogens. We evaluated the efficacy of the defensive secretion of Apfelbeckia insculpta (L. Koch, 1867) against bacteria, yeasts, and filamentous fungi. The tested secretion consisted of two compounds, p-cresol and phenol, and showed antibacterial, antibiofilm, and antifungal potential against all selected microorganisms. The most sensitive bacterium in our study was Pseudomonas aeruginosa, while the tested defensive secretion manifested the lowest activity against Escherichia coli. The defensive secretion of A. insculpta also showed an ability, albeit mild, to suppress biofilm formation by P. aeruginosa. Among the tested yeasts, Candida albicans and C. krusei were the most susceptible and most resistant species, respectively. Finally, the concentration of extracts obtained from the tested defensive secretion needed to achieve an antifungal effect was lowest in the case of Cladosporium cladosporioides. Fusarium verticillioides and Penicillium rubens were the micromycetes most resistant to the tested secretion. Our results indicate that antibacterial activity of the defensive secretion of A. insculpta is similar to or slightly weaker than that of streptomycin, while comparison with antimycotics showed that the tested millipede secretion has stronger activity than fluconazole, but weaker activity than nystatin and ketoconazole. The present study corroborates previous findings indicating that the defensive secretions of millipedes can have different roles apart from antipredator protection and are effective against pathogenic microorganisms.
URI: https://biore.bio.bg.ac.rs/handle/123456789/155
DOI: 10.1007/s00114-019-1631-z
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