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Title: | Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin | Authors: | Karaman, Maja Tesanovic, Kristina Novakovic, Aleksandra Jakovljevic, Dragica Janjusevic, Ljiljana Sibul, Filip Pejin, Boris |
Keywords: | AChE inhibitory activity;Coprinus comatus filtrate extract;new AD health promoting product;polyphenolic profile;quercetin | Issue Date: | 1-Jan-2018 | Rank: | M22 | Journal: | Natural Product Research | Abstract: | © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1542 | ISSN: | 1478-6419 | DOI: | 10.1080/14786419.2018.1533831 |
Appears in Collections: | Journal Article |
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