Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1542
Title: Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin
Authors: Karaman, Maja
Tesanovic, Kristina 
Novakovic, Aleksandra
Jakovljevic, Dragica
Janjusevic, Ljiljana
Sibul, Filip
Pejin, Boris
Keywords: AChE inhibitory activity;Coprinus comatus filtrate extract;new AD health promoting product;polyphenolic profile;quercetin
Issue Date: 1-Jan-2018
Rank: M22
Journal: Natural Product Research
Abstract: 
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1542
ISSN: 1478-6419
DOI: 10.1080/14786419.2018.1533831
Appears in Collections:Journal Article

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