Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1521
Title: Targeting astrocytes for treatment in amyotrophic lateral sclerosis
Authors: Peric, Mina 
Mitrecic, Dinko
Andjus, Pavle R. 
Keywords: AQP4;Astrocyte;Blood-brain barrier;Cell transplantation;Endfeet;IP3 receptor pathway;Kir4.1;Stem cells
Issue Date: 1-Jan-2017
Journal: Current Pharmaceutical Design
Abstract: 
© 2017 Bentham Science Publishers. Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte endfeet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1521
ISSN: 1381-6128
DOI: 10.2174/1381612823666170615110446
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