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https://biore.bio.bg.ac.rs/handle/123456789/1521
Title: | Targeting astrocytes for treatment in amyotrophic lateral sclerosis | Authors: | Peric, Mina Mitrecic, Dinko Andjus, Pavle R. |
Keywords: | AQP4;Astrocyte;Blood-brain barrier;Cell transplantation;Endfeet;IP3 receptor pathway;Kir4.1;Stem cells | Issue Date: | 1-Jan-2017 | Journal: | Current Pharmaceutical Design | Abstract: | © 2017 Bentham Science Publishers. Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte endfeet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1521 | ISSN: | 1381-6128 | DOI: | 10.2174/1381612823666170615110446 |
Appears in Collections: | Journal Article |
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