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Title: | Uloga azot-monoksid sintaza u stanjima ishemije mozga tokom karotidne endarterektomije | Other Titles: | The role of the nitric oxide synthases in brain ischemia during carotid endarterectomy | Authors: | Bogdanović, Nikola Obradović, Milan Jasnić, Nebojša Spremo-Potparević, Biljana Unić-Stojanović, Dragana Radak, Đorđe Isenović, Esma |
Keywords: | carotid endarterectomy;endothelial nitric oxide synthase;inducible nitric oxide synthase;nitric oxide;acute brain ischemia | Issue Date: | 1-Jan-2015 | Publisher: | Medicinski fakultet - Univerzitet u Beogradu | Journal: | Medicinska istraživanja | Abstract: | According to the World Health Organization, 15 million people per year are affected by stroke. The most common cause of stroke is brain ischemia, which occurs in almost 85% of cases. Ischemia caused by thromboembolism is defined as permanently or temporarily decreased blood flow which prevents an adequate delivery of oxygen, glucose and oth-er important nutrients, leading progressively to metabolic changes and cell apoptosis. Carotid endarterectomy (CEA) can cause hypoxic – ischemic states of the brain or acute brain ischemia (ABI) leading eventually to stroke. The main cause of ABI as a result of CEA is cerebral hypoperfusion caused by clamping of carotid arteries, when hypoxia occurs.. Hypoxia per se is one of the triggers of complex physiological responses in the body, including the release of various me-diators of inflammation. One of these inflammatory mediators is nitric oxide (NO), a free radical which has numerous physiological effects and also plays an important role in the immune response of the organism. However, NO may be very harmful and cause cell and tissue damage. The lack of literature data on the role of endothelial NOS (eNOS) and inducible NOS (iNOS) during CEA, as well as the mechanisms of their regulation in ischemic conditions, suggest that intensifying future research in this field is very important. An insight into molecular mechanisms of iNOS activity and expression regulation will certainly help to develop new therapeutic strategies for treating harmful effects of free radi-cals, especially uncontrolled production of NO. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/151 |
Appears in Collections: | Journal Article |
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