Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1483
Title: Effect of stab injury in the rat cerebral cortex on temporal pattern of expression of neuronal cytoskeletal proteins: An immunohistochemical study
Authors: Lavrnja, Irena
Savic, Danijela
Parabucki, Ana
Dacić, Sanja 
Laketa, Danijela 
Pekovic, Sanja
Stojiljkovic, Mirjana
Keywords: Cortical stab injury;Cytoskeleton;Immunohistochemistry;MAP-2;Neurofilaments
Issue Date: 1-Mar-2015
Journal: Acta Histochemica
Abstract: 
© 2014 Elsevier GmbH. Compelling evidence now points to the critical role of the cytoskeleton in neurodegeneration. In the present study, using an immunohistochemical approach, we have shown that cortical stab injury (CSI) in adult Wistar rats significantly affects temporal pattern of expression of neurofilament proteins (NFs), a major cytoskeleton components of neurons, and microtubule-associated proteins (MAP2). At 3 days post-injury (dpi) most of the NFs immunoreactivity was found in pyknotic neurons and in fragmentized axonal processes in the perilesioned cortex. These cytoskeletal alterations became more pronounced by 10. dpi. At the subcellular level CSI also showed significant impact on NFs and MAP-2 expression. Thus, at 3. dpi most of the dendrites disappeared, while large neuronal somata appeared like open circles pointing to membrane disintegration. Conversely, at 10. dpi neuronal perikarya and a few new apical dendrites were strongly labeled. Since aberrant NF phosphorylation is a pathological hallmark of many human neurodegenerative disorders, as well as is found after stressor stimuli, the present results shed light into the expression of neurofilaments after the stab brain injury.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1483
ISSN: 0065-1281
DOI: 10.1016/j.acthis.2014.12.004
Appears in Collections:Journal Article

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