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Title: | Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models | Authors: | Kolarević, Stoimir Milovanović, Dragana Kračun-Kolarević, Margareta Kostić, Jovana Sunjog, Karolina Martinović, Rajko Đorđević, Jelena Novaković, Irena Sladić, Dušan Vuković Gačić, Branka |
Keywords: | Avarol;SOS/umuC;mutagenicity;genotoxicity;comet assay;avarone | Issue Date: | 4-Mar-2019 | Rank: | M22 | Journal: | Drug and Chemical Toxicology | Abstract: | © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3′-methoxyavarone, 4′-(methylamino)avarone and 3′-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3′-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3′-methoxyavarone and 3′-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1464 | ISSN: | 0148-0545 | DOI: | 10.1080/01480545.2017.1413108 |
Appears in Collections: | Journal Article |
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