Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1452
Title: Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae
Authors: Vuković Gačić, Branka 
Nikčević, S.
Berić-Bjedov, T.
Knežević Vukčević, Jelena 
Simić, D.
Keywords: Antimutagens;Salmonella/microsome;Sage;S. cerevisiae;Monoterpenes;E. coli
Issue Date: 1-Jan-2006
Journal: Food and Chemical Toxicology
Abstract: 
Mutagenic and antimutagenic potential of essential oil (EO) of cultivated sage (S. officinalis L.) and its monoterpenes: thujone, 1,8-cineole, camphor and limonene against UVC-induced mutations was studied with Salmonella/microsome, E. coli WP2, E. coli K12 [Simić, D., Vuković-Gačić, B., Knežević-Vukčević, J., 1998. Detection of natural bioantimutagens and their mechanisms of action with bacterial assay-system. Mutat. Res. 402, 51-57] and S. cerevisiae D7 reversion assays. The toxicity of EO differed, depending on the strain used. The most sensitive were permeable strains TA100, TA102, E. coli K12 IB112 and non-permeable WP2. Mutagenic potential of EO and monoterpenes was not detected, with or without S9. EO reduced the number of UV-induced revertants in a concentration-dependent manner, reaching 50-70% of inhibition at the maximum non-toxic concentrations: 3 μl/plate (TA102), 5 μl/plate (WP2), 7.5 μl/plate (IB112), 30 μl/plate (E. coli K12 SY252) and 60 μl/plate (D7). The metabolic activation had no effect on antimutagenic potential of EO. Similar toxicity of monoterpenes was observed in TA100, E. coli SY252 and D7, with the exception of limonene (less toxic to D7). Reduction of UV-induced revertants by non-toxic concentrations of monoterpenes, tested with SY252 and D7, reached 40-50% at 15-20 μl/plate of thujone, 10 μl/plate of cineole and 1-10 μg/plate of camphor. Limonene showed antimutagenic effect only in D7. Our data recommend sage monoterpenes for further chemoprevention studies. © 2006 Elsevier Ltd. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1452
ISSN: 0278-6915
DOI: 10.1016/j.fct.2006.05.011
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