Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/139
Title: Protein expression of ubiquitin in interscapular brown adipose tissue during acclimation of rats to cold: The impact of •nO
Authors: Vucetic, Milica
Otasevic, Vesna
Stancic, Ana
Jankovic, Aleksandra
Markelić, Milica 
Golić, Igor 
Veličković, Ksenija 
Buzadzic, Biljana
Korać, Aleksandra 
Korać, Bato 
Keywords: Brown adipose tissue;Cold acclimation;L-Arginine;Nitric oxide;Ubiquitin
Issue Date: 1-Sep-2012
Rank: M23
Project: White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders 
Journal: Molecular and Cellular Biochemistry
Abstract: 
In this study, the effects of L-arginine-nitricoxide (•NO)-producing pathway on protein content of ubiquitin, as an important component of ubiquitin-proteasome system for protein removal, were investigated. We showed that L-arginine markedly decreased ubiquitin protein content in interscapular brown adipose tissue, both in thermogenic inactive (at room temperature) and thermogenic active (on cold) states; while in L-NAME-treated groups this effect was abolished. This result suggests that nitric oxide (•NO), besides well established roles, is involved in this aspect of structure remodeling, as well. © 2012 Springer Science+Business Media, LLC.
URI: https://biore.bio.bg.ac.rs/handle/123456789/139
ISSN: 0300-8177
DOI: 10.1007/s11010-012-1359-y
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