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https://biore.bio.bg.ac.rs/handle/123456789/139| Title: | Protein expression of ubiquitin in interscapular brown adipose tissue during acclimation of rats to cold: The impact of •nO |
| Authors: | Vucetic, Milica Otasevic, Vesna Stancic, Ana Jankovic, Aleksandra Markelić, Milica Golić, Igor Veličković, Ksenija Buzadzic, Biljana Korać, Aleksandra Korać, Bato |
| Keywords: | Brown adipose tissue;Cold acclimation;L-Arginine;Nitric oxide;Ubiquitin |
| Issue Date: | 1-Sep-2012 |
| Rank: | M23 |
| Project: | White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders |
| Journal: | Molecular and Cellular Biochemistry |
| Abstract: | In this study, the effects of L-arginine-nitricoxide (•NO)-producing pathway on protein content of ubiquitin, as an important component of ubiquitin-proteasome system for protein removal, were investigated. We showed that L-arginine markedly decreased ubiquitin protein content in interscapular brown adipose tissue, both in thermogenic inactive (at room temperature) and thermogenic active (on cold) states; while in L-NAME-treated groups this effect was abolished. This result suggests that nitric oxide (•NO), besides well established roles, is involved in this aspect of structure remodeling, as well. © 2012 Springer Science+Business Media, LLC. |
| URI: | https://biore.bio.bg.ac.rs/handle/123456789/139 |
| ISSN: | 0300-8177 |
| DOI: | 10.1007/s11010-012-1359-y |
| Appears in Collections: | Journal Article |
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