Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/123
Title: Peripheral oxytocin treatment affects the rat adreno-medullary catecholamine content modulating expression of vesicular monoamine transporter 2
Authors: Jovanović, Predrag
Spasojević, Nataša
Stefanović, Bojana
Božovic, Nevena
Jasnić, Nebojša 
Đorđević, Jelena 
Dronjak-Čučaković, Slađana
Keywords: Adrenal-medulla;Epinephrine;Norepinephrine;Oxytocin;Vesicular monoamine transporter 2
Issue Date: 1-Jan-2014
Journal: Peptides
Abstract: 
The neuropeptide oxytocin has been shown to influence on neuroendocrine function. The aim of the present study was to investigate the effect of peripheral oxytocin treatment on the synthesis, uptake and content of adreno-medullary catecholamine. For this purpose oxytocin (3.6 μg/100 g body weight, s.c) was administrated to male rats once a day over 14 days. In order to assess the effect of peripheral oxytocin treatment on adreno-medullary catecholamine we measured epinephrine and norepinephrine content and gene expression of tyrosine hydroxylase (TH), norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. Our results show a significant increase of epinephrine (1.7-fold, p < 0.05) and norepinephrine (1.5-fold, p < 0.05) content in oxytocin treated animals compared to saline treated ones. Oxytocin treatment had no effect either on mRNA or protein level of TH and NET. Under oxytocin treatment the increase in VMAT2 mRNA level was not statistically significant, but it caused a significant increase in protein level of VMAT2 (3.7-fold, p < 0.001). These findings indicate that oxytocin treatment increases catecholamine content in the rat adrenal medulla modulating VMAT2 expression.
URI: https://biore.bio.bg.ac.rs/handle/123456789/123
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2013.11.001
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