Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1206
Title: The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO- and t-BOOH-induced mutagenesis in coli
Authors: Nikolić, Biljana 
Mitić Ćulafić, Dragana 
Vuković Gačić, Branka 
Knežević Vukčević, Jelena 
Keywords: 4NQO;UV-irradiation;t-BOOH;Monoterpenes;Escherichia coli;Antimutagenesis
Issue Date: 6-Jul-2011
Journal: Archives of Biological Sciences
Abstract: 
The aim of this work was to investigate the antimutagenic potential of monoterpenes from sage and basil in Escherichia coli. The mutagenic potential of monoterpenes was pre-screened with Salmonella/microsome reversion assay in strain TA100 and no mutagenic effect was detected. The antimutagenic potential against UV- 4NQO- and t-BOOH induced mutagenesis was evaluated in E. coli K12 and E. coli WP2 by reversion assays. The obtained results indicate that camphor and thujone reduce UV- and 4NQO-induced mutations; myrcene reduces t-BOOH-induced mutations, while eucalyptol and linalool reduce mutagenicity by all tested mutagens. Considering evolutionary conservation of DNA repair and antioxidative protection, the obtained results indicate that further antigenotoxicity studies should be undertaken in eukaryotes.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1206
ISSN: 0354-4664
DOI: 10.2298/ABS1101117N
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