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Title: | Antioxidative defense organization in retroperitoneal white adipose tissue during acclimation to cold-The involvement of l-arginine/NO pathway | Authors: | Janković, Aleksandra Buzadžić, Biljana Korać, Aleksandra Petrović, Vesna Vasilijević, Ana Korać, Bato |
Keywords: | Antioxidative defense;Cold;L-Arginine;L-NAME;Nitric oxide;white adipose tissue | Issue Date: | 1-Oct-2009 | Project: | Ministry of Science and Technological Development, Republic of Serbia [143050] | Journal: | Journal of Thermal Biology | Abstract: | 1.Retroperitoneal white adipose tissue (RpWAT) antioxidative defense was investigated in untreated, l-arginine-treated and Nω-nitro-l-arginine methyl ester (l-NAME)-treated rats kept at 4±1 °C (1, 3, 7, 12, 21 and 45 days) and compared to control rats at 22±1 °C.2.Cold-acclimation-induced RpWAT weight decrease was accompanied by a decline in glutathione level and increased activity of manganese superoxide dismutase (MnSOD), glutathione S-transferase (GST), catalase, glutathione peroxidase and glutathione reductase at different time-points.3.l-arginine accelerated RpWAT weight decrease, the increase in MnSOD and GST activities and the prolonged increase of catalase, MnSOD and GST activities. l-NAME delayed cold-induced catalase activity increase and tissue weight decrease. Prolonged l-NAME-treatment had a similar effect on RpWAT as l-arginine.4.Results suggest the involvement of l-arginine/NO pathway in RpWAT oxidative metabolic augmentation induced by cold-acclimation. © 2009 Elsevier Ltd. All rights reserved. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1183 | ISSN: | 0306-4565 | DOI: | 10.1016/j.jtherbio.2009.06.007 |
Appears in Collections: | Journal Article |
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