Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1170
Title: Redox implications in adipose tissue (dys)function-A new look at old acquaintances
Authors: Jankovic, Aleksandra
Korać, Aleksandra 
Buzadzic, Biljana
Otasevic, Vesna
Stancic, Ana
Daiber, Andreas
Korać, Bato 
Keywords: Adipose tissue;Insulin resistance;Obesity;Redox
Issue Date: 1-Dec-2015
Rank: M21
Project: White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders 
Cost Action - BM1203/EU-ROS
Journal: Redox Biology
Abstract: 
Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1170
ISSN: 2213-2317
DOI: 10.1016/j.redox.2015.06.018
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