Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/1170
Title: | Redox implications in adipose tissue (dys)function-A new look at old acquaintances | Authors: | Jankovic, Aleksandra Korać, Aleksandra Buzadzic, Biljana Otasevic, Vesna Stancic, Ana Daiber, Andreas Korać, Bato |
Keywords: | Adipose tissue;Insulin resistance;Obesity;Redox | Issue Date: | 1-Dec-2015 | Rank: | M21 | Project: | White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders Cost Action - BM1203/EU-ROS |
Journal: | Redox Biology | Abstract: | Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1170 | ISSN: | 2213-2317 | DOI: | 10.1016/j.redox.2015.06.018 |
Appears in Collections: | Journal Article |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.