Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1131
Title: Divergent evolution of life span associated with mitochondrial DNA evolution
Authors: Stojković, Biljana 
Sayadi, Ahmed
Đorđević, Mirko
Jović, Jelena
Savković, Uroš
Arnqvist, Göran
Keywords: Acanthoscelides obtectus;artificial selection;Bruchinae;coadaptation;mitochondria;mtDNA;negative frequency dependent selection;senescence
Issue Date: 1-Jan-2017
Publisher: Society for the Study of Evolution
Journal: Evolution
Abstract: 
Mitochondria play a key role in ageing. The pursuit of genes that regulate variation in life span and ageing have shown that several nuclear-encoded mitochondrial genes are important. However, the role of mitochondrial encoded genes (mtDNA) is more controversial and our appreciation of the role of mtDNA for the evolution of life span is limited. We use replicated lines of seed beetles that have been artificially selected for long or short life for >190 generations, now showing dramatic phenotypic differences, to test for a possible role of mtDNA in the divergent evolution of ageing and life span. We show that these divergent selection regimes led to the evolution of significantly different mtDNA haplotype frequencies. Selection for a long life and late reproduction generated positive selection for one specific haplotype, which was fixed in most such lines. In contrast, selection for reproduction early in life led to both positive selection as well as negative frequency-dependent selection on two different haplotypes, which were both present in all such lines. Our findings suggest that the evolution of life span was in part mediated by mtDNA, providing support for the emerging general tenet that adaptive evolution of life-history syndromes may involve mtDNA.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1131
ISSN: 0014-3820
DOI: 10.1111/evo.13102
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