Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/111
Title: Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?
Authors: Otasevic, Vesna
Korać, Aleksandra 
Vucetic, Milica
Macanovic, Biljana
Garalejic, Eliana
Ivanovic-Burmazovic, Ivana
Filipovic, Milos R.
Buzadzic, Biljana
Stancic, Ana
Jankovic, Aleksandra
Veličković, Ksenija 
Golić, Igor 
Markelić, Milica 
Korać, Bato 
Keywords: sperm cell;Mitochondria;Redox regulation
Issue Date: 10-Jan-2013
Rank: M21a
Project: Reactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertility 
Journal: Antioxidants and Redox Signaling
Abstract: 
Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide (.NO), the number of MitoTracker® Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as.NO might be involved in the observed effects of the mimic. © 2013, Mary Ann Liebert, Inc.
URI: https://biore.bio.bg.ac.rs/handle/123456789/111
ISSN: 1523-0864
DOI: 10.1089/ars.2012.4684
Appears in Collections:Journal Article

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