Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1099
Title: Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children
Authors: Damnjanović, Tatjana
Luković, Ljiljana
Cvetković, Dragana 
Jekić, Biljana
Bunjevački, Vera
Maksimović, Nela
Cvjeticanin, Suzana
Majkić-Singh, Nada
Slavko, S.
Novaković, Ivana
Keywords: Atherosclerosis;Lipid levels;MTHFR 677T allele;MTHFR gene;Polymorphism;Schoolchildren
Issue Date: 1-Jan-2014
Publisher: Institut za Bioloska Istrazivanja
Journal: Archives of Biological Sciences
Abstract: 
The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on serum lipid profiles is controversial. We randomly selected 530 healthy schoolchildren that were included in the Yugoslav Study of the Precursors of Atherosclerosis in School Children (YUSAD). The detected frequencies of MTHFR 677TT genotypes and MTHFR 677T allele were 13.4% and 35.5%, respectively. The mean levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides were higher and high-density lipoprotein cholesterol was lower in the group of children with TT genotype compared with remaining genotypes. All differences were without statistical significance. Our findings suggest that there is no influence of MTHFR C677T gene variants on the lipid parameters in the population of Serbian children.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1099
ISSN: 0354-4664
DOI: 10.2298/ABS1402729D
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