Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1097
Title: Introduction to Molecular genetic diagnostics
Authors: Novaković, Ivana
Maksimović, Nela
Pavlović, Aleksandra
Žarkovć, Milena
Rovčanin, Branislav
Mirković, Duško
Pekmezović, Tatjana
Cvetković, Dragana 
Keywords: Genetic counselling;Methods;Molecular genetics;Test
Issue Date: 1-Jan-2014
Publisher: Society of Medical Biochemists of Serbia and Montenegro
Journal: Journal of Medical Biochemistry
Abstract: 
Molecular genetic testing is part of modern medical practice. DNA tests are an essential part of diagnostics and genetic counseling in single gene diseases, while their application in polygenic disorders is still limited. Phar - ma cogenetics studies DNA variants associated with variations in drug efficacy and toxicity, and tests in this field are being deve loped rapidly. The main method for molecular genetic testing is the polymerase chain reaction, with a number of modifications. New methods, such as next generation sequencing and DNA microarray, should allow simultaneous analysis of a number of genes, even whole genome sequencing. Ethical concerns in molecular genetic testing are very important, along with legislation. After molecular genetic testing, interpretation of results and genetic counseling should be done by professionals. With the example of thrombophilia, we discuss questions about genetic testing, its possibilities and promises.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1097
ISSN: 1452-8258
DOI: 10.2478/jomb-2013-0039
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