Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/109
Title: Differences in the redox status of human visceral and subcutaneous adipose tissues - Relationships to obesity and metabolic risk
Authors: Jankovic, Aleksandra
Korać, Aleksandra 
Srdic-Galic, Biljana
Buzadzic, Biljana
Otasevic, Vesna
Stancic, Ana
Vucetic, Milica
Markelić, Milica 
Veličković, Ksenija 
Golić, Igor 
Korać, Bato 
Keywords: Metabolic syndrome;Metabolism;Redox regulation
Issue Date: 1-Jan-2014
Rank: M22
Project: White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders 
Reactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertility 
Journal: Metabolism: Clinical and Experimental
Abstract: 
Objective Metabolic homeostasis depends on adipocyte metabolic responses/processes, most of which are redox-regulated. Besides, visceral and subcutaneous adipose tissues (VAT and SAT, respectively) differ metabolically and in their contribution to metabolic complications, but their redox characteristics in humans are still unknown. To understand the molecular mechanisms of metabolic syndrome development, we analysed the redox characteristics of VAT and SAT in groups with various body weights and metabolic risks. Material and Methods Fifty premenopausal women were classified according to body mass index into normal-weight and obese groups, and these groups were further sub-classified into metabolically healthy and metabolically obese ("at risk") based on the homeostasis model assessment of insulin resistance (HOMA-IR) index and the triglyceride, total-, LDL- and HDL-cholesterol levels. Antioxidant components, NADPH oxidase protein and 4-hydroxynonenal (4-HNE) levels were analysed in VAT and SAT. Results Compared with the SAT, the VAT showed a higher basal level of glutathione (GSH) and GSH-dependent enzyme activities. Compared with the metabolically healthy normal-weight controls, the obese groups of women showed lower GSH levels in both depots. However, in these groups, additional prooxidative changes (increased NADPH oxidase and 4-HNE and decreased levels of SOD and/or CAT) were observed only in VAT. Conclusions Because of the critical role of thiol-redox homeostasis in lipogenesis, interdepot-differences in the GSH-dependent antioxidant part may be connected to the higher metabolic activity found in VAT. Analogously, the lower GSH levels that occur during obesity and the corresponding additional redox imbalance may be signs of VAT metabolic dysfunction that underlie the subsequent metabolic impairment. © 2014 Elsevier Inc. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/109
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2014.01.009
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