Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/107
Title: Endocrine and metabolic signaling in retroperitoneal white adipose tissue remodeling during cold acclimation
Authors: Jankovic, Aleksandra
Korać, Aleksandra 
Buzadzic, Biljana
Otasevic, Vesna
Stancic, Ana
Vucetic, Milica
Markelić, Milica 
Veličković, Ksenija 
Golić, Igor 
Korać, Bato 
Keywords: white adipose tissue;cold acclimation;endocrine signaling;metabolic signaling
Issue Date: 27-May-2013
Project: White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders 
Journal: Journal of Obesity
Abstract: 
The expression profiles of adiponectin, resistin, 5′-AMP-activated protein kinase α (AMPKα), hypoxia-inducible factor-1α (HIF-1α), and key enzymes of glucose and fatty acid metabolism and oxidative phosphorylation in rat retroperitoneal white adipose tissue (RpWAT) during 45-day cold acclimation were examined. After transient suppression on day 1, adiponectin protein level increased following sustained cold exposure. In parallel, on day 1, the protein level of HIF-1α was strongly induced and AMPKα suppressed, while afterwards the reverse was seen. What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochrome c oxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed. Similar to adiponectin, protein level of resistin showed a biphasic profile: it increased after days 1, 3, and 7 and decreased below the control after 21 days of cold-acclimation. In summary, the data suggest that adiponectin and resistin are important integrators of RpWAT metabolic response and roles it plays during cold acclimation. It seems that AMPKα mediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation. © 2013 Aleksandra Jankovic et al.
URI: https://biore.bio.bg.ac.rs/handle/123456789/107
ISSN: 2090-0708
DOI: 10.1155/2013/937572
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