Electrochemical characterization of oxaprozin on bare gold electrode and electrode modified with bovine serum albumin

Abstract

As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug, using cyclic voltammetry on gold electrode in 0.05 mol dm-3 NaHCO3, the synthesized drug, its analytical standard and its content in Duraprox® tablets were characterized with one oxidation reaction and the three reduction reactions. All they exhibited the linear concentration dependency of anodic currents at 0.83V for the analytical standard and 0.85V for Duraprox® tablets in the range of concentrations 8.44 - 32.78×10-6 mol dm-3. The strong adsorption of bovine serum albumin (BSA) on gold electrode in 0.1 mol dm-3 phosphate buffer solution (pH 7.4) is shown and concentration dependency of anodic currents of oxaprozin standard on BSA / Au is studied. Following the Langmuir adsorption thermodynamic equation, the binding constants of oxaprozin on BSA / Au electrode was calculated with the results 1.23×105 dm3 mol-1. © 2012 by ESG.