Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7618
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dc.contributor.authorPerović, Tatjanaen_US
dc.contributor.authorLazović, Biljanaen_US
dc.contributor.authorAdakalić, Mirjanaen_US
dc.contributor.authorDžamić, Anaen_US
dc.contributor.authorŽarković, Lazaren_US
dc.contributor.authorGašić, Urošen_US
dc.contributor.authorKostić, Marinaen_US
dc.contributor.authorPetrović, Jovanaen_US
dc.contributor.authorStojković, Dejanen_US
dc.contributor.authorĆirić, Anaen_US
dc.date.accessioned2025-03-04T08:42:35Z-
dc.date.available2025-03-04T08:42:35Z-
dc.date.issued2025-01-15-
dc.identifier.issn2405-8440-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7618-
dc.description.abstractJujube (Ziziphus jujuba Mill.) is a highly abundant wild-growing plant in Montenegro. It has been utilized since old times for various bioactive properties by the natives, however its detailed chemical characterization, antimicrobial, antioxidant and cytotoxic potential have not been extensively explored. Herein, we used crud methanol extract and three fractions (methylene chloride, n-butanol and aqueous) to asses bioactive features of fruits from this wild growing edible plant, after which we performed the targeted analysis of phenolic compounds of n-butanol fraction by (UHPLC-DAD-MS/MS). Our antioxidant assays showed the highest radical scavenging potential for n-butanol fraction using DPPH and ABTS methods. As for the antimicrobial activity of extract and three fractions, generally aqueous showed the least promising antibacterial and antifungal properties, whereas methylene chloride, methanol and n-butanol fractions showed quite promising antimicrobial potential. E. coli and S. aureus strains were the most susceptible to the compounds present in the methylene chloride and n-butanol fractions with MIC of 0.01-0.025 mg/mL, and MBC 0.025-0.05 mg/mL, along with MRSA strain, which was the most susceptible to the effects of methanol extract with MIC of 0.10 mg/mL and MBC 0.15 mg/mL. The results of antifungal activity showed lower potential to inhibit growth of pathogenic fungi than bacteria, whereas cytotoxicity assay showed extracts have no effects towards HaCaT skin cell line.The n-butanol fraction had the overall most promising activity, and therefore was subjected to more in depth chemical analysis.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofHeliyonen_US
dc.subjectBiological activityen_US
dc.subjectChemical compositionen_US
dc.subjectEdible fruitsen_US
dc.subjectZiziphus jujubaen_US
dc.titleInsights into bioactivity guided chemical profiling of Ziziphus jujuba Mill. fruits wild-growing in Montenegroen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.heliyon.2024.e41361-
dc.identifier.pmid39811273-
dc.identifier.scopus2-s2.0-85212654046-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85212654046-
dc.description.rankM22en_US
dc.description.impact3.4en_US
dc.description.startpagee41361en_US
dc.relation.issn2405-8440en_US
dc.description.volume11en_US
dc.description.issue1en_US
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
crisitem.author.deptChair of Plant Morphology and Systematics-
crisitem.author.deptChair of Plant Morphology and Systematics-
crisitem.author.orcid0000-0002-1984-7207-
crisitem.author.orcid0000-0001-6033-6559-
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