Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7354
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dc.contributor.authorDobrijević, Zoranaen_US
dc.contributor.authorRajovski, Srećkoen_US
dc.contributor.authorMatijašević Joković, Suzanaen_US
dc.contributor.authorMilanović, Nikoletaen_US
dc.contributor.authorRadovanović, Nemanjaen_US
dc.contributor.authorBrkušanin, Milošen_US
dc.contributor.authorSavić-Pavićević, Dušankaen_US
dc.contributor.authorBrajušković, Goranen_US
dc.date.accessioned2024-11-01T09:10:49Z-
dc.date.available2024-11-01T09:10:49Z-
dc.date.issued2024-
dc.identifier.issn1452-8266-
dc.identifier.issn1452-8258-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7354-
dc.description.abstractBackground: miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and diseases of the reproductive system. The aim of this study was to investigate the association between the two functional genetic variants in the hsa-miR-27a (rs2910164) and hsa-miR-146a gene (rs895819) and male infertility in North Macedonian population, as well as to test their association with the values of major seminal parameters. Methods: The case group included in this study comprised 158 men initially diagnosed with idiopathic male infertility. The control group included 126 age-matched healthy male volunteers who fathered at least one child. Results: We report for the first time the association of rs2910164 minor allele C with the increased susceptibility to asthenoteratozoospermia. Additionally, our results indicating the association of allele C with low sperm vitality are a novel finding. We did not demonstrate the association between genetic variant rs895819 and the risk of different types of male infertility. Still, the number of participants with CC genotype in subjects diagnosed with asthenoteratozoospermia was null, while in controls it reached 7.2%. We further detected the rs895819 genotype-dependent difference in rapid progressive sperm motility. Conclusions: The association of rs2910164 and rs895819 with idiopathic male infertility in general is unlikely. However, both of these variants show association with certain types of male infertility and with sperm abnormalities, which need to be confirmed in later studies in different ethnic groups.en_US
dc.language.isoenen_US
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versitaen_US
dc.relation.ispartofJournal of Medical Biochemistryen_US
dc.subjectMale infertility;en_US
dc.subjectrs2910164;en_US
dc.subjectrs895819;en_US
dc.subjectPoly- morphism;en_US
dc.subjectmiR-27a;en_US
dc.subjectmiR-146a.en_US
dc.titleAssociation between genetic variants in hsa-miR-27a and hsa-miR-146a gene and male infertilityen_US
dc.typeArticleen_US
dc.identifier.doi10.5937/jomb0-50876-
dc.description.rankM23en_US
dc.description.impact2.5en_US
dc.description.startpage43en_US
dc.relation.issn1452-8258en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0002-0592-8890-
crisitem.author.orcid0000-0002-4316-9231-
crisitem.author.orcid0000-0002-2079-4077-
crisitem.author.orcid0000-0002-3935-6755-
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