Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7326
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dc.contributor.authorPetrović, Jovanaen_US
dc.contributor.authorGlamočlija, Jasminaen_US
dc.contributor.authorCvetković, Stefanaen_US
dc.contributor.authorNikolić, Biljanaen_US
dc.contributor.authorGašić, Urošen_US
dc.contributor.authorRobajac, Draganaen_US
dc.date.accessioned2024-10-24T07:28:09Z-
dc.date.available2024-10-24T07:28:09Z-
dc.date.issued2024-10-16-
dc.identifier.issn0148-0545-
dc.identifier.issn1525-6014-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7326-
dc.description.abstractIn the present study, phenolic and flavonoid composition and biological properties of methanolic extract of wild growing Paxillus involutus collected in Serbia have been investigated. Ellagic acid was the most abundant phenolic compound (34.92 µg g-1), followed by 5-O-caffeoylquinic acid (4.51 µg g-1), whereas isoorientin was the most abundant flavonoid (3.42 µg g-1). P. involutus turned out to be a rich source of phenolic compounds (74.67 mg GAE g-1 d.w.), whereas total flavonoid content was significantly lower (4.05 mg QE g-1 d.w.). As for the various investigated biological activities, methanolic extract exerted high level of antioxidant, antimicrobial and antibiofilm activities. The highest antioxidative potential was measured by TAC (350 TE mg g-1 d.w.), whereas evaluation of antimicrobial properties showed selective antimicrobial potential toward tested pathogenic microorganisms, with resistant strain of E. coli being the most susceptible to the activity of the extract (MIC 0.08 mg mL-1, MBC 0.16 mg mL-1). Furthermore, methanolic extract of P. involutus demonstrated genotoxicity, severe hemolysis effects and selective cytotoxicity against colon cancer cells. From the obtained data, it may be concluded that investigated mushroom albeit being toxic for human consumption, may be considered as a source of highly bioactive components with potential application in drug development.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Inc.en_US
dc.relation.ispartofDrug and chemical toxicologyen_US
dc.subjectChemical characterizationen_US
dc.subjectantimicrobial potentialen_US
dc.subjectantioxidanten_US
dc.subjectcytotoxicityen_US
dc.subjectgenotoxicityen_US
dc.titleExploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fren_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1080/01480545.2024.2412776-
dc.identifier.pmid39412001-
dc.description.rankM23en_US
dc.description.impact2.100en_US
dc.description.startpage1en_US
dc.description.endpage11en_US
dc.relation.issn0148-0545en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0001-9214-4682-
crisitem.author.orcid0000-0003-1765-2454-
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