Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7317
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dc.contributor.authorSmailagić, Dijanaen_US
dc.contributor.authorDragišić Maksimović, Jelenaen_US
dc.contributor.authorMarin, Marijaen_US
dc.contributor.authorStupar, Sofijaen_US
dc.contributor.authorNinković, Slavicaen_US
dc.contributor.authorBanjac, Nevenaen_US
dc.contributor.authorStanišić, Marianaen_US
dc.date.accessioned2024-10-23T10:34:15Z-
dc.date.available2024-10-23T10:34:15Z-
dc.date.issued2024-09-19-
dc.identifier.issn01761617-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7317-
dc.description.abstractPhloretin is a key secondary metabolite produced by apple trees. Known for its strong antioxidant properties, this dihydrochalcone has been extensively studied in animals but less so in plants. Recently, we identified phloretin as a phytotoxic allelochemical that inhibits growth in the model plant Arabidopsis by disrupting auxin metabolism and distribution in the roots. In this study, we found that phloretin significantly hinders the growth of Arabidopsis seedlings' aerial parts after a short-term treatment (10 days) and causes their decay after long-term exposure (28 days). These effects result from ultrastructural damage in the mesophyll cells of the leaves, including chloroplast displacement and swelling, lesions, and alterations in thylakoid and cell wall organization. Interestingly, phloretin-treated plants showed a decrease in malondialdehyde levels and antioxidant enzyme activities, while hydrogen peroxide and proline levels remained unchanged. This suggests that phloretin-induced chlorosis and seedling decay are not due to oxidative stress but rather to severe chloroplast structural damage, leading to inefficient photosynthesis, starch degradation, starvation, and activation of micro- and macroautophagic processes for self-preservation. Ultimately, these processes result in programmed cell death. These new insights into the phytotoxic effects of phloretin on Arabidopsis shoots could pave the way for future research into phloretin as a potential multitarget bioherbicide and enhance our understanding of autoallelopathy in apple trees.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of plant physiologyen_US
dc.subjectAllelochemicalen_US
dc.subjectAntioxidative enzymesen_US
dc.subjectAutophagyen_US
dc.subjectCell ultrastructureen_US
dc.subjectDihydrochalconeen_US
dc.subjectMalusen_US
dc.subjectPhotosynthetic pigmentsen_US
dc.titlePhloretin inhibits the growth of Arabidopsis shoots by inducing chloroplast damage and programmed cell deathen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.jplph.2024.154354-
dc.identifier.pmid39341101-
dc.identifier.scopus2-s2.0-85204928986-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85204928986-
dc.description.rankM21en_US
dc.description.impact4.3en_US
dc.description.startpage154354en_US
dc.relation.issn0176-1617en_US
dc.description.volume303en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0003-1560-116X-
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