Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7279
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dc.contributor.authorRepac, Jelenaen_US
dc.contributor.authorBožić, Bojanen_US
dc.contributor.authorBožić Nedeljković, Biljanaen_US
dc.date.accessioned2024-09-13T10:19:29Z-
dc.date.available2024-09-13T10:19:29Z-
dc.date.issued2024-09-06-
dc.identifier.issn12864579-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7279-
dc.description.abstractCutibacterium acnes, common resident of the human skin, can establish both commensal and pathogenic relations with the human host; however, long-term consequences of C. acnes-induced inflammation remained un(der)explored. To infer the capacity of triggering autoimmunity in humans via molecular mimicry, a comprehensive immunoinformatics analysis of the experimentally characterized C. acnes proteome was performed. The protocol included homology screening between the C. acnes and the human proteome, and validation of shared specificity regions against the collection of experimentally characterized T-cell epitopes, related to autoimmunity. To obtain highly reliable predictions, the results were subjected to additional cross-validation by a dedicated MHC-restriction analysis, including a docking study of C. acnes mimotopes and human counterparts with the highest degree of sequence similarity to MHCII molecules representing the highest risk for detected autoimmune pathologies. Due to mimicking of highly immunogenic, but also evolutionary conserved autoantigens from the Heat Shock protein family, association between C. acnes and the pathogenesis of highly incident autoimmune diseases: Type 1 Diabetes, Rheumatoid Arthritis, and Juvenile Idiopathic Arthritis, was found. To the best of our knowledge, this study is the first one to provide preliminary information and a mechanistic link on the putative involvement of C. acnes in the pathogenesis of autoimmunity in humans.en_US
dc.language.isoenen_US
dc.publisherElsevier France ^Editions Scientifiques et Medicalesen_US
dc.relation.ispartofMicrobes and infectionen_US
dc.subjectCutibacterium acnesen_US
dc.subjectHeat Shock proteinen_US
dc.subjectJuvenile Idiopathic Arthritisen_US
dc.subjectMolecular mimicryen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectType 1 Diabetesen_US
dc.titleCutibacterium acnes as an overseen autoimmunity trigger: Unearthing heat-shock driven molecular mimicryen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.micinf.2024.105420-
dc.identifier.pmid39245175-
dc.description.rankM21en_US
dc.description.impact5.8en_US
dc.description.startpage105420en_US
dc.relation.issn1286-4579en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0001-9910-2741-
crisitem.author.orcid0000-0002-1238-1731-
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