Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7278
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dc.contributor.authorLunić, Tanjaen_US
dc.contributor.authorPetković, Milošen_US
dc.contributor.authorRakić, Marijaen_US
dc.contributor.authorLađarević, Jelenaen_US
dc.contributor.authorRepac, Jelenaen_US
dc.contributor.authorBožić Nedeljković, Biljanaen_US
dc.contributor.authorBožić, Bojanen_US
dc.date.accessioned2024-09-10T08:50:14Z-
dc.date.available2024-09-10T08:50:14Z-
dc.date.issued2024-08-25-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7278-
dc.description.abstractThis study explores the anti-neuroinflammatory and antioxidant potential of 42 hydroxybenzoic acid esters and three parent acids. Molecular docking simulations targeted key proteins involved in the lipopolysaccharide (LPS) signaling pathway to identify lead compounds for synthesis and in vitro evaluation. Among the screened esters, the most promising candidates demonstrated antioxidant activity comparable to vitamin C in ABTS and DPPH assays. Additionally, these esters significantly reduced the production of reactive oxygen species (ROS) and nitric oxide (NO) in H2O2- and LPS-stimulated BV2 microglial cells, indicating their ability to attenuate neuro- inflammation. Further testing in SH-SY5Y neuronal cells exposed to microglia-derived supernatants confirmed the neuroprotective effects of these esters, reducing microglia-mediated neurotoxicity. These results suggest that hydroxybenzoic acid ester derivatives are promising candidates for mitigating microglia-driven neuro- inflammation and protecting neurons, offering potential therapeutic applications for neurodegenerative diseases.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.subjectHydroxybenzoic ester derivatives;en_US
dc.subjectNeuroprotection;en_US
dc.subjectNeuroinflammation;en_US
dc.subjectAntioxidant;en_US
dc.subjectMicroglia.en_US
dc.titleAnti-neuroinflammatory potential of hydroxybenzoic ester derivatives: In silico insight and in vitro validationen_US
dc.typeJournal Articleen_US
dc.description.rankM22en_US
dc.description.impact4.0en_US
dc.description.startpage139804en_US
dc.relation.issn0022-2860en_US
dc.description.volume1321en_US
dc.description.issue2025en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0002-1238-1731-
crisitem.author.orcid0000-0001-9910-2741-
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