Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7253
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dc.contributor.authorOalđe Pavlović, Marianaen_US
dc.contributor.authorKolarević, S.en_US
dc.contributor.authorĐorđević Aleksić, J.en_US
dc.contributor.authorVuković-Gačić, Brankaen_US
dc.date.accessioned2024-08-02T07:55:19Z-
dc.date.available2024-08-02T07:55:19Z-
dc.date.issued2024-05-30-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7253-
dc.description.abstractIn response to the global rise in antibiotic resistance and the prevalence of bacterial biofilm-related infections, the antibacterial efficacy of methanolic, ethanolic, and aqueous extracts of 18 Lamiaceae plants from Serbia was evaluated. The total coumarins and triterpenes were detected spectrophotometrically, while a microdilution assay measured their effects on bacterial growth. Additionally, the impact of these extracts was assessed on Pseudomonas aeruginosa PAO1 adhesion and invasion in human fibroblasts and biofilm formation and degradation. The alcoholic extracts had the highest phytochemical content, with Teucrium montanum and Lavandula angustifolia being the richest in coumarins and triterpenes, respectively. Gram-positive bacteria, particularly Bacillus subtilis, were more susceptible to the extracts. Hyssopus officinalis ethanolic and Sideritis scardica methanolic extracts inhibited bacterial growth the most efficiently. Although the extracts did not inhibit bacterial adhesion, most ethanolic extracts significantly reduced bacterial invasion. Origanum vulgare and H. officinalis ethanolic extracts significantly inhibited biofilm formation, while Teucrium chamaedrys extract was the most active in biofilm degradation. This study significantly contributes to the literature by examining the antibacterial activity of Lamiaceae extracts, addressing major literature gaps, and underscoring their antibacterial potential, particularly Satureja montana and O. vulgare ethanolic extracts, linking their efficacy to coumarins and triterpenes.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPlantsen_US
dc.subjectLamiaceae extracts;en_US
dc.subjectMIC;en_US
dc.subjectPseudomonas aeruginosa PAO1;en_US
dc.subjectBacterial invasion;en_US
dc.subjectBiofilm formation;en_US
dc.subjectBiofilm degradation.en_US
dc.titleExploring the antibacterial potential of Lamiaceae plant extracts: Inhibition of bacterial growth, adhesion, invasion, and biofilm formation and degradation in Pseudomonas aeruginosa PAO1en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3390/plants13121616-
dc.description.rankM21en_US
dc.description.impact4.0en_US
dc.relation.issn2223-7747en_US
dc.description.volume13en_US
dc.description.issue12en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Plant Morphology and Systematics-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0001-9338-7811-
crisitem.author.orcid0000-0001-8767-1912-
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