Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7189
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dc.contributor.authorMarija Brankovićen_US
dc.contributor.authorTijana Gmizićen_US
dc.contributor.authorMarija Dukićen_US
dc.contributor.authorMarija Zdravkovićen_US
dc.contributor.authorBranislava Daskalovićen_US
dc.contributor.authorDavor Mrdaen_US
dc.contributor.authorNovica Nikolićen_US
dc.contributor.authorMilica Brajkovićen_US
dc.contributor.authorMilan Gojgićen_US
dc.contributor.authorJovana Lalatovićen_US
dc.contributor.authorĐorđe Kraljen_US
dc.contributor.authorIvana Pantićen_US
dc.contributor.authorMarko Vojnovićen_US
dc.contributor.authorTamara Milovanovićen_US
dc.contributor.authorĐurašević, Sinišaen_US
dc.contributor.authorZoran Todorovićen_US
dc.date.accessioned2024-05-15T08:40:50Z-
dc.date.available2024-05-15T08:40:50Z-
dc.date.issued2024-05-14-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7189-
dc.description.abstractPalmitoylethanolamide (PEA) is an endocannabinoid-like bioactive lipid mediator belonging to the family of N-acylethanolamines, most abundantly found in peanuts and egg yolk. When the gastrointestinal (GI) effects of PEA are discussed, it must be pointed out that it affects intestinal motility but also modulates gut microbiota. This is due to anti-inflammatory, antioxidant, analgesic, antimicrobial, and immunomodulatory features. Additionally, PEA has shown beneficial effects in several GI diseases, particularly irritable bowel syndrome and inflammatory bowel diseases, as various studies have shown, and it is important to emphasize its relative lack of toxicity, even at high dosages. Unfortunately, there is not enough endogenous PEA to treat disturbed gut homeostasis, even though it is produced in the GI tract in response to inflammatory stimuli, so exogenous intake is mandatory to achieve homeostasis. Intake of PEA could be through animal and/or vegetable food, but bearing in mind that a high dosage is needed to achieve a therapeutic effect, it must be compensated through dietary supplements. There are still open questions pending to be answered, so further studies investigating PEA’s effects and mechanisms of action, especially in humans, are crucial to implementing PEA in everyday clinical practice.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectpalmitoylethanolamideen_US
dc.subjectgastrointestinal tracten_US
dc.subjectanti-inflammatoryen_US
dc.subjectantioxidantsen_US
dc.subjectIBSen_US
dc.subjectIBDen_US
dc.titleTherapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disordersen_US
dc.typeReview Articleen_US
dc.identifier.doihttps://doi.org/10.3390/antiox13050600-
dc.description.rankM21en_US
dc.description.impact7.0en_US
dc.description.startpage600en_US
dc.relation.doihttps://doi.org/10.3390/antiox13050600en_US
dc.relation.issn2076-3921en_US
dc.coverage.publicationPalmitoylethanolamideen_US
dc.description.volume13en_US
dc.description.issue5en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeReview Article-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0003-4406-8376-
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