Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6706
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dc.contributor.authorTodorovic, Smiljaen_US
dc.contributor.authorSimeunovic, Valentinaen_US
dc.contributor.authorPrvulovic, Milicaen_US
dc.contributor.authorDakić, Tamaraen_US
dc.contributor.authorJevđović, Tanjaen_US
dc.contributor.authorSokanovic, Srdjanen_US
dc.contributor.authorKanazir, Selmaen_US
dc.contributor.authorMladenovic, Aleksandraen_US
dc.date.accessioned2023-11-24T11:40:05Z-
dc.date.available2023-11-24T11:40:05Z-
dc.date.issued2023-11-17-
dc.identifier.issn0951-6433-
dc.identifier.issn1872-8081-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6706-
dc.description.abstractInsulin is known to be a key hormone in the regulation of peripheral glucose homeostasis, but beyond that, its effects on the brain are now undisputed. Impairments in insulin signaling in the brain, including changes in insulin levels, are thought to contribute significantly to declines in cognitive performance, especially during aging. As one of the most widely studied experimental interventions, dietary restriction (DR) is considered to delay the neurodegenerative processes associated with aging. Recently, however, data began to suggest that the onset and duration of a restrictive diet play a critical role in the putative beneficial outcome. Because the effects of DR on insulin signaling in the brain have been poorly studied, we decided to examine the effects of DR that differed in onset and duration: long-term DR (LTDR), medium-term DR (MTDR), and short-term DR (STDR) on the expression of proteins involved in insulin signaling in the hippocampus of 18- and 24-month-old male Wistar rats. We found that DR-induced changes in insulin levels in the brain may be independent of what happens in the periphery after restricted feeding. Significantly changed insulin content in the hippocampus, together with altered insulin signaling were found under the influence of DR, but the outcome was highly dependent on the onset and duration of DR.en_US
dc.language.isoenen_US
dc.publisherI O S Pressen_US
dc.relation.ispartofBioFactors (Oxford, England)en_US
dc.subjectagingen_US
dc.subjectdietary restrictionen_US
dc.subjectdurationen_US
dc.subjecthippocampusen_US
dc.subjectinsulinen_US
dc.subjectinsulin receptoren_US
dc.subjectonseten_US
dc.titleDietary restriction alters insulin signaling pathway in the brainen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1002/biof.2018-
dc.identifier.pmid37975613-
dc.description.rankM21en_US
dc.description.impact6.438en_US
dc.relation.issn0951-6433en_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-7238-2728-
crisitem.author.orcid0000-0001-6047-9365-
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