Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6438
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dc.contributor.authorBadraiq, Hebaen_US
dc.contributor.authorČvoro, Aleksandraen_US
dc.contributor.authorGalleu, Antonioen_US
dc.contributor.authorSimon, Marisaen_US
dc.contributor.authorMiere, Cristianen_US
dc.contributor.authorHobbs, Carlen_US
dc.contributor.authorSchulz, Reineren_US
dc.contributor.authorSiow, Richarden_US
dc.contributor.authorDazzi, Francescoen_US
dc.contributor.authorIlić, Duškoen_US
dc.date.accessioned2023-11-08T11:58:35Z-
dc.date.available2023-11-08T11:58:35Z-
dc.date.issued2017-12-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6438-
dc.description.abstractWe investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese (BMI = 19-25; n = 7) and obese (BMI ≥ 30; n = 7) donors undergoing elective Cesarean section, we found that WJ MSC from obese donors showed slower population doubling and a stronger immunosuppressive activity. Genome-wide DNA methylation of triple positive (CD73+CD90+CD105+) WJ MSCs found 67 genes with at least one CpG site where the methylation difference was ≥0.2 in four or more obese donors. Only one gene, PNPLA7, demonstrated significant difference on methylome, transcriptome and protein level. Although the number of analysed donors is limited, our data suggest that the altered metabolic environment related to excessive body weight might bear consequences on the WJ MSCs.en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUP, LONDON, ENGLANDen_US
dc.relation.ispartofScientific Reportsen_US
dc.titleEffects of maternal obesity on Wharton’s Jelly mesenchymal stromal cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-017-18034-1-
dc.description.rankM21en_US
dc.description.impact5.228en_US
dc.description.startpage17595en_US
dc.relation.issn2045-2322en_US
dc.description.volume7en_US
dc.description.issue1en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0009-0007-5643-1634-
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