Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6148
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dc.contributor.authorStanojević, S.en_US
dc.contributor.authorKuštrimović, N.en_US
dc.contributor.authorMitić, K.en_US
dc.contributor.authorMiletić, T.en_US
dc.contributor.authorVujić, V.en_US
dc.contributor.authorKovačević-Jovanović, V.en_US
dc.contributor.authorDimitrijević, M.en_US
dc.date.accessioned2023-06-02T08:29:45Z-
dc.date.available2023-06-02T08:29:45Z-
dc.date.issued2008-08-05-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6148-
dc.description.abstractBackground: Given that stressful experiences can change the reaction to a subsequent exposure to stress, we tested the in vitro effects of the stress mediator corticosterone and the opioid peptide β-endorphin on the function of macrophages isolated from control rats and from rats exposed to electric tail shock stress (ES) or a stress-witnessing procedure (SW) 24 h earlier. Methods: Peritoneal macrophages isolated from control and stressed rats of the Dark Agouti (DA) strain were treated in vitro with corticosterone or β-endorphin and tested for adherence, phagocytosis and hydrogen peroxide release. Results: ES diminished adherence and SW decreased phagocytosis. The suppressive effect of corticosterone on phagocytosis was absent in rats exposed to ES and SW, while the suppressive effect of β-endorphin on adherence was not observed in rats exposed to SW. ES and SW did not affect H2O2 release, neither directly nor indirectly by changing macrophage response to corticosterone and β-endorphin in this test. Conclusions: In DA rats early macrophage activation steps, i.e. adherence and phagocytosis, were more sensitive to stress than their effector function, corresponding to H2O2 production. We suggest that neuroendocrine mediators of stress that converge on macrophages might have changed specific macrophage receptors or postreceptor events and alter their response to artificial stressors, represented by corticosterone and β-endorphin in vitro.en_US
dc.language.isoenen_US
dc.publisherKarger, Baselen_US
dc.relation.ispartofNeuroimmunomodulationen_US
dc.subjectCorticosterone;en_US
dc.subjectDark Agouti rats;en_US
dc.subjectElectric tail shock stress;en_US
dc.subjectBeta-endorphinen_US
dc.subjectPeritoneal macrophages;en_US
dc.subjectStress-witnessing procedureen_US
dc.titleThe Effects of Corticosterone and Beta-Endorphin on Adherence, Phagocytosis and Hydrogen Peroxide Production of Macrophages Isolated from Dark Agouti Rats Exposed to Acute Stressen_US
dc.typeArticleen_US
dc.identifier.doi10.1159/000148193-
dc.description.rankM23en_US
dc.description.impact1,212en_US
dc.description.startpage108en_US
dc.description.endpage116en_US
dc.relation.issn1021-7401en_US
dc.description.volume15en_US
dc.description.issue2en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0003-0091-8797-
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