Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6114
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dc.contributor.authorKostić-Vuković, Jovanaen_US
dc.contributor.authorKolarević, Stoimiren_US
dc.contributor.authorSunjog, Karolinaen_US
dc.contributor.authorSubotić, Srđanen_US
dc.contributor.authorVišnjić-Jeftić, Željkaen_US
dc.contributor.authorRašković, Božidaren_US
dc.contributor.authorPoleksić, Vesnaen_US
dc.contributor.authorVuković-Gačić, Brankaen_US
dc.contributor.authorLenhardt, Mirjanaen_US
dc.date.accessioned2023-05-18T10:25:59Z-
dc.date.available2023-05-18T10:25:59Z-
dc.date.issued2023-05-16-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6114-
dc.description.abstractIn this study a battery of bioassays, both in vivo (metals and metalloids concentrations, erythrocyte morphometry, comet assay, micronucleus assay, and histopathological analyses) on vimba bream Vimba vimba (L., 1758) and white bream Blicca bjoerkna (L., 1758), and in vitro (treatment of HepG2 cells with native water samples) was applied to assess the harmful potential of untreated wastewater. Faecal indicator bacteria were quantified to assess the microbiological water quality. Vimba bream had significantly higher Fe concentrations in both liver and muscle, while white bream had higher Ca and Cu concentrations in liver. Vimba bream had a significantly higher level of DNA damage in both liver and blood cells, in comparison to white bream. Low levels of micronucleus and nuclear abnormalities were observed in both species. Erythrocytes morphometry did not show significant interspecific differences. Histopathological analyses revealed a similar response of the studied species, with a significantly higher presence of ceroid pigments in the liver of vimba bream. Treatment of HepG2 cells revealed the high genotoxic potential of water downstream of the discharge point. The results of this study clearly demonstrate the importance of effect-based monitoring, in order to enforce more efficient management of natural resources and implementation of wastewater treatment systems.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEcotoxicologyen_US
dc.subjectMetals accumulation;en_US
dc.subjectErythrocyte morphometry;en_US
dc.subjectComet assay;en_US
dc.subjectMicronucleus;en_US
dc.subjectHistopathology;en_US
dc.subjectHepG2.en_US
dc.titleCombined use of biomarkers to assess the impact of untreated wastewater from the Danube River, Serbiaen_US
dc.typeJournalen_US
dc.identifier.doi10.1007/s10646-023-02663-6-
dc.description.rankM22en_US
dc.description.impact2.935en_US
dc.relation.issn0963-9292en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Animal Ecology and Zoogeography-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0002-9597-2288-
crisitem.author.orcid0000-0001-8767-1912-
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