Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5715
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dc.contributor.authorAnđelkov, Katarinaen_US
dc.contributor.authorEremin, Ilya I.en_US
dc.contributor.authorKorać, Aleksandraen_US
dc.date.accessioned2023-03-20T11:00:39Z-
dc.date.available2023-03-20T11:00:39Z-
dc.date.issued2022-07-01-
dc.identifier.issn0906-6705-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5715-
dc.description.abstractHair folliculogenesis and hair growth mediated by the secretory properties of white adipocytes may pave the way for the adipose-derived (AD) regenerative therapy for androgenetic alopecia (AGA). Quantitative and qualitative secretome profiling of AD stem cells (ADSCs) from different zones of hair growth in patients with AGA were analysed. 1-mm punch samples of adipose tissue associated with hair follicles, of three scalp areas (balding, non-balding and transition zones) and one periumbilical sample, were used for ADCS isolation. The ADCS secretome was analysed in conditioned media using a 41plex assay. Among the thirty-five signalling proteins analysed, the levels of VEGF, EGF, IL-6, Eotaxin, MCP-3, IFNγ-inducible protein-10 and MIP-1α were higher in the balding zone compared with the non-balding and periumbilical zones. In contrast, MCP-1 was the lowest in the balding zone in comparison with the other zones. The observed differences in the secretome suggest crosstalk between angiogenic and inflammatory processes underlying AGA aetiology and may prove relevant in both the diagnosis of AGA and the application of ADSC secretome for AGA treatment.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofExperimental Dermatologyen_US
dc.subjectAdipose-derived stem cellsen_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectHair follicleen_US
dc.subjectSecretomeen_US
dc.titleDifferent levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1α in the adipose-derived stem cell secretome in androgenetic alopeciaen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/exd.14548-
dc.description.rankM21en_US
dc.description.impact4.511en_US
dc.description.startpage936en_US
dc.description.endpage942en_US
dc.description.volume31en_US
dc.description.issue6en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
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