Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5714
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dc.contributor.authorProtić, Isidoraen_US
dc.contributor.authorGolić, Igoren_US
dc.contributor.authorVidaković, Snežanaen_US
dc.contributor.authorKorać, Batoen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.date.accessioned2023-03-20T11:00:28Z-
dc.date.available2023-03-20T11:00:28Z-
dc.date.issued2022-07-31-
dc.identifier.issn1467-3037-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5714-
dc.description.abstractZinc (in the form of Zn2+) is necessary for male fertility. Both Zn2+ quantity and its localisation have been detected in seminal plasma and ejaculated spermatozoa, suggesting its active uptake via zinc import transporters (ZIPs). Immunofluorescence was used to characterise the expression and localisation of three distinct types of ZIP transporters in ejaculated spermatozoa of normo- and asthenozoospermic sperm samples. ZIP6, ZIP10 and ZIP14 showed heterogeneous sperm cell expression and different compartmental distribution. In both types of sperm samples, ZIP6 and ZIP14 were predominantly localised in the sperm head, while ZIP10 was found along the sperm tail. Compartmental localisation of ZIPs in asthenozoospermia was not changed. However, regarding sub-compartmental localisation in sperm head regions, for ZIP6 asthenozoospermia only decreased its acorn/crescent-like pattern. In contrast, ZIP14 immunostaining was altered in favour of crescent-like, as opposed to acorn-like and acorn/crescent-like patterns. The specific ZIPs localisation may reflect their different roles in sperm cell integrity and motility and may change over time. This is the first report of their specific compartmental and sub-compartmental localisation in ejaculated human sperm cells. Further research will lead to a greater understanding of the roles of ZIPs in sperm cell biology, which could positively influence procedures for human infertility therapy.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofCurrent Issues in Molecular Biologyen_US
dc.subjectZIPen_US
dc.subjectAsthenozoospermiaen_US
dc.subjectMale infertilityen_US
dc.subjectNormozoospermiaen_US
dc.subjectZincen_US
dc.titleHeterogeneous Immunolocalisation of Zinc Transporters ZIP6, ZIP10 and ZIP14 in Human Normo- and Asthenozoospermic Spermatozoaen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cimb44080237-
dc.description.rankM23en_US
dc.description.impact2.976en_US
dc.description.startpage3444en_US
dc.description.endpage3454en_US
dc.description.volume44en_US
dc.description.issue8en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0001-5944-5053-
crisitem.author.orcid0000-0001-5272-579X-
crisitem.author.orcid0000-0002-3044-9963-
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