Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5285
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dc.contributor.authorNikolić, Biljanaen_US
dc.contributor.authorMitić-Ćulafić, Draganaen_US
dc.contributor.authorVuković-Gačić, Brankaen_US
dc.contributor.authorKnežević-Vukčević, Jelenaen_US
dc.date.accessioned2023-02-08T09:49:27Z-
dc.date.available2023-02-08T09:49:27Z-
dc.date.issued2011-09-
dc.identifier.isbn978- 3-319-55529-4-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5285-
dc.descriptionIn Handbook of Nutrition, Diet, and Epigenetics.en_US
dc.description.abstractThe aim of this work was to examine the antigenotoxic potential of plant monoterpenes: camphor, eucalyptol and thujone in prokaryotic and eukaryotic cells and to elucidate their effect on DNA repair. We compared the effect of monoterpenes on spontaneous, UV- and 4NQO-induced mutagenesis in Escherichia coli K12 repair proficient, and MMR and NER deficient strains. Positive controls tannic acid and vanillin were included in bacterial tests. We also examined protective effect of monoterpenes against 4NQO-induced genotoxicity in Vero cell line by alkaline comet assay. The results obtained in repair proficient strain indicated antimutagenic potential of monoterpenes against UV- and 4NQO-induced mutagenesis, which was diminished with NER deficiency. Camphor and eucalyptol maintained UV-induced SOS response longer than in controls, while thujone decreased SOS response and reduced general protein synthesis and the growth rate. The three monoterpenes increased spontaneous and UV-induced recombination in recA730 and camphor additionally in recA(+) cells. Incubation of 4NQO-pretreated Vero cells with monoterpenes resulted in significant reduction of tail moment. However, higher concentrations of monoterpenes induced DNA strand breaks. Obtained results indicate that by making a small amount of DNA lesions camphor, eucalyptol and thujone can stimulate error-free DNA repair processes and act as bioantimutagens.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.subjectMonoterpenen_US
dc.subjectAntigenotoxicityen_US
dc.subjectDNA repairen_US
dc.subjectEscherichia coli K12en_US
dc.subjectVero cellsen_US
dc.titlePlant Monoterpenes Camphor, Eucalyptol, Thujone, and DNA Repairen_US
dc.typeBook Chapteren_US
dc.identifier.doi10.1016/j.fct.2011.05.015-
dc.description.rankM13en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeBook Chapter-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0003-1765-2454-
crisitem.author.orcid0000-0002-6651-6814-
crisitem.author.orcid0000-0001-8767-1912-
crisitem.author.orcid0000-0002-8138-6579-
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