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Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5197
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dc.contributor.authorLibis, Vincent K.en_US
dc.contributor.authorBernheim, Aude G.en_US
dc.contributor.authorBasier, Clovisen_US
dc.contributor.authorJaramillo-Riveri, Sebastiánen_US
dc.contributor.authorDeyell, Matthewen_US
dc.contributor.authorAghoghogbe, Idonnyaen_US
dc.contributor.authorAtanasković, Ivaen_US
dc.contributor.authorBencherif, Amel Caméliaen_US
dc.contributor.authorBenony, Margueriteen_US
dc.contributor.authorKoutsoubelis, Nicolasen_US
dc.contributor.authorLöchner, Anne C.en_US
dc.contributor.authorMarinković, Zoran S.en_US
dc.contributor.authorZahra, Sarahen_US
dc.contributor.authorZegman, Yonatanen_US
dc.contributor.authorLindner, Ariel B.en_US
dc.contributor.authorWintermute, Edwin H.en_US
dc.date.accessioned2022-11-23T12:04:56Z-
dc.date.available2022-11-23T12:04:56Z-
dc.date.issued2014-12-19-
dc.identifier.citationBacteriophage Technology and Modern Medicine. Azam AH, Tan XE, Veeranarayanan S, Kiga K, Cui L. Antibiotics (Basel). 2021 Aug 18;10(8):999. doi: 10.3390/antibiotics10080999. PMID: 34439049 Free PMC article. Review. Rekindling of a Masterful Precedent; Bacteriophage: Reappraisal and Future Pursuits. Abd-Allah IM, El-Housseiny GS, Yahia IS, Aboshanab KM, Hassouna NA. Front Cell Infect Microbiol. 2021 May 31;11:635597. doi: 10.3389/fcimb.2021.635597. eCollection 2021. PMID: 34136415 Free PMC article. Review. The bactericidal efficacy of femtosecond laser-based therapy on the most common infectious bacterial pathogens in chronic wounds: an in vitro study. Ahmed E, El-Gendy AO, Moniem Radi NA, Mohamed T. Lasers Med Sci. 2021 Apr;36(3):641-647. doi: 10.1007/s10103-020-03104-0. Epub 2020 Jul 28. PMID: 32725427 Advances in engineered trans-acting regulatory RNAs and their application in bacterial genome engineering. Ahmed W, Hafeez MA, Ahmed R. J Ind Microbiol Biotechnol. 2019 Jun;46(6):819-830. doi: 10.1007/s10295-019-02160-y. Epub 2019 Mar 18. PMID: 30887255 Review. Phage Therapy in the Postantibiotic Era. Gordillo Altamirano FL, Barr JJ. Clin Microbiol Rev. 2019 Jan 16;32(2):e00066-18. doi: 10.1128/CMR.00066-18. Print 2019 Apr. PMID: 30651225 Free PMC article. Review.en_US
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5197-
dc.description.abstractIn response to emergent antibiotic resistance, new strategies are needed to enhance the effectiveness of existing antibiotics. Here, we describe a phagemid-delivered, RNA-mediated system capable of directly knocking down antibiotic resistance phenotypes. Small regulatory RNAs (sRNAs) were designed to specifically inhibit translation of chloramphenicol acetyltransferase and kanamycin phosphotransferase. Nonlytic phagemids coding for sRNA expression were able to infect and restore chloramphenicol and kanamycin sensitivity to populations of otherwise resistant E. coli. This modular system could easily be extended to other bacteria with resistance profiles that depend on specific transcripts.en_US
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofACS Synthetic Biologyen_US
dc.titleSilencing of antibiotic resistance in E. coli with engineered phage bearing small regulatory RNAsen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/sb500033d-
dc.description.rankM21en_US
dc.description.impact4,978en_US
dc.description.startpage1003en_US
dc.description.endpage1006en_US
dc.description.volume3en_US
dc.description.issue12en_US
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
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