Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5175
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dc.contributor.authorJovanović, Bogdanen_US
dc.contributor.authorEiermann, Ninaen_US
dc.contributor.authorTalwar, Deeptien_US
dc.contributor.authorBoulougouri, Mariaen_US
dc.contributor.authorDick, Tobias P.en_US
dc.contributor.authorStoecklin, Georgen_US
dc.date.accessioned2022-11-23T08:15:00Z-
dc.date.available2022-11-23T08:15:00Z-
dc.date.issued2021-08-11-
dc.identifier.citationBogdan Jovanovic, Nina Eiermann, Deepti Talwar, Maria Boulougouri, Tobias P. Dick, Georg Stoecklin, Thioredoxin 1 is required for stress granule assembly upon arsenite-induced oxidative stress, Food and Chemical Toxicology, Volume 156, 2021, 112508, ISSN 0278-6915, https://doi.org/10.1016/j.fct.2021.112508. (https://www.sciencedirect.com/science/article/pii/S027869152100541X)en_US
dc.identifier.issn0278-6915-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5175-
dc.description.abstractArsenic is a major water pollutant and health hazard, leading to acute intoxication and, upon chronic exposure, several diseases including cancer development. Arsenic exerts its pronounced cellular toxicity through its trivalent oxide arsenite (ASN), which directly inhibits numerous proteins including Thioredoxin 1 (Trx1), and causes severe oxidative stress. Cells respond to arsenic by inhibition of protein synthesis and subsequent assembly of stress granules (SGs), cytoplasmic condensates of stalled mRNAs, translation factors and RNA-binding proteins. The biological role of SGs is diverse and not completely understood; they are important for regulation of cell signaling and survival under stress conditions, and for adapting de novo protein synthesis to the protein folding capacity during the recovery from stress. In this study, we identified Trx1 as a novel component of SGs. Trx1 is required for the assembly of ASN-induced SGs, but not for SGs induced by energy deprivation or heat shock. Importantly, our results show that Trx1 is essential for cell survival upon acute exposure to ASN, through a mechanism that is independent of translation inhibition.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.subjectArsenicen_US
dc.subjectStress responseen_US
dc.subjectOxidative stressen_US
dc.subjectThioredoxinen_US
dc.subjectStress granulesen_US
dc.titleThioredoxin 1 is required for stress granule assembly upon arsenite-induced oxidative stressen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fct.2021.112508-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S027869152100541X-
dc.description.rankM21en_US
dc.description.impact5.572en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0001-8613-797X-
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