Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/5038
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dc.contributor.authorStanojević, Jelenaen_US
dc.contributor.authorDragić, Miloraden_US
dc.contributor.authorStevanović, Ivanaen_US
dc.contributor.authorIlić, Tihomiren_US
dc.contributor.authorStojanović, Ivanaen_US
dc.contributor.authorZeljković, Milicaen_US
dc.contributor.authorNinković, Milicaen_US
dc.date.accessioned2022-11-10T12:06:37Z-
dc.date.available2022-11-10T12:06:37Z-
dc.date.issued2022-09-05-
dc.identifier.issn0166-4328-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/5038-
dc.description.abstractIntracerebroventricularly (icv) injected streptozotocin (STZ) model of Alzheimer's disease (AD) is used to explore the effect of intermittent theta burst stimulation (iTBS) on astrocyte and microglia reactivity in selectively vulnerable brain regions and answer the question whether these changes are in the context of cognitive capacity. The iTBS is a non-invasive approach for stimulating neuronal and glial activity with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for different neurological diseases, including AD. Male Wistar rats were assigned to five groups: 1. Control subjected to icv saline solution, 2. STZ subjected to icv-STZ (bilaterally, 3 mg/kg), 3. STZ+iTBS subjected to iTBS therapy after icv-STZ, 4. STZ+iTBS placebo subjected to noise artifact after icv-STZ and 5. Control+iTBS subjected to iTBS therapy after icv- saline solution. The RotaRod result showed that STZ did not alter motor function in rats. Eight arm radial maze test results showed that iTBS significantly improved cognitive impairment induced by STZ intoxication. Reactive gliosis in the hippocampus and periventricular area, manifested through elevated levels of Iba1+ and GFAP+/VIM+ following icv-STZ, was ameliorated after iTBS treatment. Our research identifies iTBS as an effective therapeutic candidate against STZ-induced neurotoxicity and AD-like changes. The beneficial effects of iTBS on cognitive dysfunction might be due to targeting microglia and astrocytes, as they exert a protective role in neurodegenerative and neuroinflammatory diseases. The results could provoke translation into clinical practice as an early/add-on non-invasive therapeutic intervention for cognitive impairment in AD.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAstrocytesen_US
dc.subjectCognitive impairmenten_US
dc.subjectITBSen_US
dc.subjectMicrogliaen_US
dc.subjectStreptozotocinen_US
dc.titleIntermittent theta burst stimulation ameliorates cognitive impairment and hippocampal gliosis in the Streptozotocin-induced model of Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbr.2022.113984-
dc.description.rankM20en_US
dc.description.impact3.352en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0003-4855-6131-
crisitem.author.orcid0000-0002-5608-4384-
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