Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4992
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dc.contributor.authorJovčić, B.en_US
dc.contributor.authorMalešević, M.en_US
dc.contributor.authorKojić, M.en_US
dc.contributor.authorGalić, N.en_US
dc.contributor.authorTodorović, D.en_US
dc.contributor.authorVidanović, D.en_US
dc.contributor.authorVelhner, M.en_US
dc.date.accessioned2022-11-08T12:35:07Z-
dc.date.available2022-11-08T12:35:07Z-
dc.date.issued2022-09-19-
dc.identifier.issn1535-3141-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4992-
dc.description.abstractOwing to the emerging resistance to antimicrobials in Salmonella Kentucky isolates around the globe, the genomic comparison of all the registered multidrug-resistant Salmonella Kentucky isolates in Serbia (five from humans, one from turkey flock, and one from meat) was done. Most of the isolates were isolated from patients returning from Egypt or Tunisia or originated from imported turkey flock and turkey meat. The comparative analysis of resistance and virulence genes was done. All isolates belonged to sequence type-ST198 and were resistant to ciprofloxacin (Cip). The resistance to Cip was mediated by target mutations of the gyrA and parC genes, which encode topoisomerase I and II, respectively. Multidrug-resistant phenotype to aminoglycosides, β-lactam antibiotics, sulfonamides, and tetracyclines was detected in five isolates. However, none of the isolates was pan-resistant to antimicrobials. The number of single nucleotide polymorphisms between isolates varied from 8 to 43 and phylogenomics revealed the genetic proximity of the human isolate 10475/11 and the turkey meat isolate 5264/14, indicating a possible meat-to-human transfer. All isolates belonged to the main Salmonella Kentucky MDR lineage, carrying the Salmonella genomic island 1 (SGI1-K) subtype. The SGI1-K of Serbian isolates showed mosaicism attributed to rapid intraclonal evolution. Many virulence factors were detected in all the isolates, including SPI-1, SPI-2, SPI-3, SPI-4, SPI-5, SPI-9, and C63PI. Although Salmonella Kentucky has rarely been isolated from humans, food, and animals in Serbia, further surveillance is needed to diminish the risk of the spreading of resistant clones and their meat-to-human transmission.en_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Inc. Publishersen_US
dc.relation3,788en_US
dc.relation.ispartofFoodborne Pathogens and Disease.en_US
dc.subjectAntibiotic resistanceen_US
dc.subjectGenomicsen_US
dc.subjectHumanen_US
dc.subjectTurkeyen_US
dc.subjectVirulenceen_US
dc.titleGenomic analysis of multidrug-resistant Salmonella enterica serovar Kentucky isolates from humans, turkey, and food in the Republic of Serbiaen_US
dc.typeArticleen_US
dc.identifier.doi10.1089/fpd.2022.0029.-
dc.description.rankM22en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0002-9500-3786-
Appears in Collections:Journal Article
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