Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4832
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dc.contributor.authorAjduković, Majaen_US
dc.contributor.authorVučić, Tijanaen_US
dc.contributor.authorCvijanović, Milenaen_US
dc.contributor.authorFilipović, Brankoen_US
dc.contributor.authorŠošić-Jurjević, Brankaen_US
dc.date.accessioned2022-11-02T09:52:40Z-
dc.date.available2022-11-02T09:52:40Z-
dc.date.issued2022-09-08-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4832-
dc.description.abstractAmphibians are useful bioindicators for monitoring aquatic health and the influence of xenobiotics such as endocrine disrupting chemicals. Because aquatic ecosystems experience the majority of global pollution, aquatic organisms are most exposed and vulnerable to endocrine disruptors. Furthermore, penetration of endocrine disruptors into aquatic organisms especially in amphibians is even easier because of more permeable skin, resulting in high bioavailability and bioaccumulation of chemicals. One of the most potent endocrine disruptors is thiourea, which chemically blocks the synthesis of thyroid hormones and prevents metamorphosis in amphibians. We investigated the influence of thiourea on histomorphology of the thyroid gland in Triturus newts at the metamorphic stage, when thyroid hormone concentrations should reach their maximum level. Chronic exposure to thiourea induced hypertrophy and hyperplasia of follicular cells as well as a significant reduction of interstitial tissue. The intensity of the thyroglobulin immunostaining signal significantly decreases upon chronic exposure to thiourea. Successful cross-reactivity of human primary antibody in immunochemical detection of thyroglobulin in Urodela confirms potential homology in thyroglobulin structure throughout the vertebrates.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofZoologyen_US
dc.subjectCaudataen_US
dc.subjectEndocrine disrupting chemicalsen_US
dc.subjectEndocrine glanden_US
dc.subjectSalamandersen_US
dc.titleChanges in thyroid histomorphology and thyroglobulin immunostaining upon exposure to thiourea in Triturus newtsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.zool.2022.126050.-
dc.description.rankM21en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Morphology, Systematics and Phylogeny of Animals-
crisitem.author.orcid0000-0002-8850-5251-
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