Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4700
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dc.contributor.authorRadovanović, J.en_US
dc.contributor.authorAntonijević, B.en_US
dc.contributor.authorKolarević, S.en_US
dc.contributor.authorMilutinović-Smiljanić, S.en_US
dc.contributor.authorMandić, J.en_US
dc.contributor.authorVuković-Gačić, B.en_US
dc.contributor.authorBulat, Z.en_US
dc.contributor.authorĆurčić, M.en_US
dc.contributor.authorKračun-Kolarević, M.en_US
dc.contributor.authorSunjog, K.en_US
dc.contributor.authorKostić-Vuković, J.en_US
dc.contributor.authorMarić, J.J.en_US
dc.contributor.authorAntonijević- Miljaković, E.en_US
dc.contributor.authorĐukić-Ćosić, D.en_US
dc.contributor.authorDjordjevic, A.B.en_US
dc.contributor.authorJavorac, D.en_US
dc.contributor.authorBaralić, K.en_US
dc.contributor.authorMandinić, Z.en_US
dc.date.accessioned2022-10-31T11:57:35Z-
dc.date.available2022-10-31T11:57:35Z-
dc.date.issued2021-
dc.identifier.issn0045-6535-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4700-
dc.description.abstractThe aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140-190 g, were divided into four experimental groups (n=5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofChemosphereen_US
dc.subjectDNA damageen_US
dc.subjectComet assayen_US
dc.subjectNaFen_US
dc.subjectSubacute toxicityen_US
dc.subjectWistar ratsen_US
dc.titleGenotoxicity of fluoride subacute exposure in rats and selenium interventionen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.chemosphere.2020.128978-
dc.description.rankM21en_US
dc.description.impact7.086en_US
dc.description.startpage128978en_US
dc.description.volume266en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0001-8767-1912-
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