Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4620
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dc.contributor.authorLunić, Tanjaen_US
dc.contributor.authorMandić, Marijaen_US
dc.contributor.authorPavlović Oalđe, Mariaen_US
dc.contributor.authorSabovljević, Anetaen_US
dc.contributor.authorSabovljević, Markoen_US
dc.contributor.authorBožić-Nedeljković, Biljanaen_US
dc.contributor.authorBožić, Bojanen_US
dc.date.accessioned2022-10-13T08:09:02Z-
dc.date.available2022-10-13T08:09:02Z-
dc.date.issued2022-01-01-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4620-
dc.description.abstractNumerous representatives of mosses, including Hypnum cupressiforme, have been used toalleviate different inflammation-related conditions. However, the mode of action underlying thisanti-inflammatory potential has been poorly understood. Moreover, the influence of seasonalityon the chemical composition and biological activity of mosses is generally overlooked. This studyaimed to investigate the influence of seasonal changes (spring, summer, and autumn) on secondarymetabolite composition and biological activities of ethyl acetate H. cupressiforme extracts. Antioxidantactivity was measured usingβ-carotene bleaching assay, while MTT, NBT, ELISA, and Griess assayswere carried out to explore the anti-neuroinflammatory and neuroprotective potential of extracts.Inhibitory activities on acetylcholinesterase and tyrosinase were assessed experimentally and bydocking analysis. The highest content of secondary metabolites and antioxidant activity wereobserved in moss during the summer. Extracts inhibited the secretion of ROS, NO, TNF-α, andIL-6, alleviating the inflammatory potential of H2O2and LPS in microglial and neuronal cells.Strong inhibitory effects on acetylcholinesterase and tyrosinase were observedin vitro. Dockinganalyses revealed high-affinity interactions of secondary metabolites present in H. cupressiforme withimportant enzyme residues. Altogether, these results reveal the neuroprotective potential and thesignificance of seasonal fluctuations on secondary metabolite content and biological activities in mossH. cupressiformeen_US
dc.publisherMDPIen_US
dc.relation.ispartofPlantsen_US
dc.subjectBryophytesen_US
dc.subjectMoss extracten_US
dc.subjectHypnum cupressiformeen_US
dc.subjectSeasonal changesen_US
dc.subjectSecondary metabolitesen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnti-neurodegenerativeen_US
dc.subjectNeuroprotectionen_US
dc.subjectMolecular dockingen_US
dc.titleThe Influence of Seasonality on Secondary Metabolite Profiles and Neuroprotective Activities of Moss Hypnum cupressiforme Extracts: In Vitro and In Silico Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/plants11010123-
dc.description.rankM21en_US
dc.description.impact4,658en_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of Plant Morphology and Systematics-
crisitem.author.deptChair of Plant Physiology-
crisitem.author.deptChair of Plant Ecology and Phytogeography-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0003-1417-8320-
crisitem.author.orcid0000-0001-9338-7811-
crisitem.author.orcid0000-0003-3092-9972-
crisitem.author.orcid0000-0001-5809-0406-
crisitem.author.orcid0000-0002-1238-1731-
crisitem.author.orcid0000-0001-9910-2741-
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