Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4583
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dc.contributor.authorJanković, Aleksandraen_US
dc.contributor.authorZakić, Tamaraen_US
dc.contributor.authorMiličić, Miroslaven_US
dc.contributor.authorUnić-Stojanović, Draganaen_US
dc.contributor.authorKalezić, Andjelikaen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorJović, Miomiren_US
dc.contributor.authorKorać, Batoen_US
dc.date.accessioned2022-07-06T16:14:42Z-
dc.date.available2022-07-06T16:14:42Z-
dc.date.issued2021-11-29-
dc.identifier.citationJankovic, Aleksandra, Tamara Zakic, Miroslav Milicic, Dragana Unic-Stojanovic, Andjelika Kalezic, Aleksandra Korac, Miomir Jovic, and Bato Korac. 2021. "Effects of Remote Ischaemic Preconditioning on the Internal Thoracic Artery Nitric Oxide Synthase Isoforms in Patients Undergoing Coronary Artery Bypass Grafting" Antioxidants 10, no. 12: 1910. https://doi.org/10.3390/antiox10121910en_US
dc.identifier.issn2076-3921-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4583-
dc.description.abstractRemote ischaemic preconditioning (RIPC) is a medical procedure that consists of repeated brief periods of transient ischaemia and reperfusion of distant organs (limbs) with the ability to provide internal organ protection from ischaemia. Even though RIPC has been successfully applied in patients with myocardial infarction during coronary revascularization (surgery/percutaneous angioplasty), the underlying molecular mechanisms are yet to be clarified. Thus, our study aimed to determine the role of nitric oxide synthase (NOS) isoforms in RIPC-induced protection (3 × 5 min of forearm ischaemia with 5 min of reperfusion) of arterial graft in patients undergoing urgent coronary artery bypass grafting (CABG). We examined RIPC effects on specific expression and immunolocalization of three NOS isoforms - endothelial (eNOS), inducible (iNOS) and neuronal (nNOS) in patients' internal thoracic artery (ITA) used as a graft. We found that the application of RIPC protocol leads to an increased protein expression of eNOS, which was further confirmed with strong eNOS immunopositivity, especially in the endothelium and smooth muscle cells of ITA. The same analysis of two other NOS isoforms, iNOS and nNOS, showed no significant differences between patients undergoing CABG with or without RIPC. Our results demonstrate RIPC-induced upregulation of eNOS in human ITA, pointing to its significance in achieving protective phenotype on a systemic level with important implications for graft patency.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofAntioxidantsen_US
dc.subjectCoronary artery graften_US
dc.subjectInternal thoracic arteryen_US
dc.subjectNitric oxide synthase isoformsen_US
dc.subjectRemote ischaemic preconditioningen_US
dc.titleEffects of Remote Ischaemic Preconditioning on the Internal Thoracic Artery Nitric Oxide Synthase Isoforms in Patients Undergoing Coronary Artery Bypass Graftingen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/antiox10121910-
dc.description.rankM21aen_US
dc.description.impact7.886en_US
dc.description.startpage1910en_US
dc.description.volume10en_US
dc.description.issue12en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
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